MagIC's Magnets

We are leveraging giant magnetoresistance (GMR) to advance molecular diagnostics. Our GMR biosensors are the magic behind ultra-high sensitivity and multiplex capabilities.

Novel GMR Biosensor Detection Method

GMR Biosensors

Giant Magnetoresistance

64-sensor array

Substrate for multiplexed DNA hybridization

Similar to DNA microarrays

Local proximity magnetic sensor

This first-of-its-kind GMR technology enables an all-in-one workflow of performing multiplexed PCR and DNA detection on a single GMR sensor chip.

Elaine Ng, PhD, CSO Magic Lifescience

What is Giant Magnetoresistance?

What is Giant Magnetoresistance?

  • Quantum mechanical effect unique to layered
    thin films
  • Electrical resistance of a GMR sensor is
    dependent on magnetic alignment of thin film
    layers
  • GMR sensors detect minute changes in local
    magnetic field when magnetic nanoparticles
    (MNPs) bind (see animation)
  • GMR signal is quantitative with respect to
    number of MNPs bound to nanosensor
  • Low limits of detection (50 aM) and high
    dynamic range (6 logs)

How are GMR sensors made?

Modern microelectromechanical systems (MEMS) fabrication technology

↓

Easy to make with high yield and low cost

Compatible with standard integrated circuit (IC) fabrication

↓

Processor and sensors can be miniaturized and integrated on one chip

Why GMR Technology for Molecular Diagnostics?

Foregoing Fluorescence

  • Low natural biological magnetism enables lower noise and higher sensitivity
  • Smaller and less expensive instrumentation                                 
  • GMR microarray chips are highly multiplexable - up to 64 targets on a single chip

Nano-materials, Big Solutions

  • Standard lithographic fabrication processes are scalable and highly cost-effective
  • GMR sensing is matrix insensitive - can directly test crude biofluids (blood, plasma, urine, saliva, etc.)
  • Localized GMR sensing simplifies workflow, enabling rapid turnaround time and total automation